The Under is the safe bet here, as both sides could struggle to score more than 24 points. Both teams will want to establish the run and lean on their defenses to win this game. Seahawks vs 49ers Best Bet: Under 52 (-110) at BetMGMĭivisional matchups tend to be lower-scoring, and that is especially true when it comes to Seattle and San Francisco.

Read our full NFL Week 4 Seahawks vs 49ers predictions and best bets.

Betting the Seahawks to win the game outright isn’t a bad call either. This is likely a game that comes down to the final possession, so getting a three-point advantage is huge here. And with Seattle having the better quarterback in this game, it’s tough to pick against them on the point spread. The Seahawks have had a ton of success against the 49ers recently, winning 13 of their last 15 meetings. Seahawks vs 49ers Prediction: Seahawks 24, 49ers 21 Seahawks vs 49ers Best Bet: Seahawks +3 (-110) at BetMGM

Seattle in particular will be looking to bounce back from a 1-2 start, so expect Russell Wilson to play with more urgency and find a way to win this huge game in Week 4.

These NFC West foes have played in multiple thrillers that have literally come down to the final play and sometimes the final yard.īoth teams are coming off rough Week 3 losses and need wins to keep pace with the Los Angeles Rams and the Arizona Cardinals in the division, both of whom remain undefeated. One of the best rivalries in the NFL over the last decade has been between the Seattle Seahawks and San Francisco 49ers. NFL Week 4 Best Bets Seattle Seahawks vs San Francisco 49ers Read Chris Wassel’s Caesars Sportsbook review for more insight and get your welcome bonus below, or continue reading this analysis for our Week 4 tipster picks. Marcus Mosher’s Best Bets NFL Betting Record: 14-4īefore you bet on Week 4 of NFL action, you should know that Caesars Sportsbook is among the industry’s best, offering tons of promotions and a fantastic $5,000 risk-free welcome bonus to new signups using our promo code. All odds are current as of Monday, September 27. To prepare you for the week ahead, here are our best bets for Week 4 in our NFL prediction and picks series. Week 4 promises to be another great week with several fascinating contests and matchups. We went 4-2 total, bringing our overall record up to 14-4. Week 3 of the NFL season was another profitable one for us with our best bets.

Week 4 nfl best bets